Tampa, FL (Oct. 9, 2009) —  Moffitt Cancer Center will celebrate the honor of being named a center of excellence by Fertile Hope from 5:30 to 8:30 p.m. Oct. 26 in the Ted & Marty Couch Auditorium at the Vincent A. Stabile Research Building, 12902 Magnolia Drive.

Fertile Hope is a national nonprofit fertility organization providing resources and support for cancer patients. The Fertile Hope Center of Excellence Program is the first of its kind to address fertility preservation and parenthood options. It is designed to ensure that all age-appropriate cancer patients are informed of their fertility risks before treatment.

Moffitt is being honored for the information received by all patients on the issues of reproductive risks and fertility preservation options.

The celebratory event will feature expert speakers including CEO and Center Director William S. Dalton, Ph.D., M.D., and associate faculty member Gwendolyn P. Quinn, Ph.D.

Quinn will speak on behalf of Moffitt and the newly developed LIVESTRONG Fertility Advisory Committee. The Lance Armstrong Foundation and Fertile Hope united to develop the committee. Quinn has been appointed for a two-year term and will help guide the foundation on how to best meet the reproductive needs of those affected by cancer.

Quinn will discuss fertility and options for cancer patients. Other experts from Moffitt, Fertile Hope, the Lance Armstrong Foundation and USF IVF & Reproductive Endocrinology will share the latest information on cancer and fertility.

Patients, families, friends and medical staff are invited to celebrate the acceptance of the award and to hear the latest information on cancer and fertility.

Please R.S.V.P. by Oct. 20 at 1-888-MOFFITT.

To qualify as a Fertile Hope Center of Excellence, cancer centers must demonstrate that:

• All individuals of reproductive age who are treated for cancer are given complete information, both verbally and in writing, about their reproductive risks and options for preserving fertility before cancer therapy, radiation, chemotherapy and surgery are initiated.
• Educational resources are available for health care professionals, patients and survivors.
• Referrals are provided to appropriate specialists for fertility preservation and parenthood after cancer.

About Fertile Hope
Fertile Hope is a national, nonprofit organization dedicated to providing reproductive information, support and hope to cancer patients whose medical treatments present the risk of infertility. In addition to robust programs in areas of awareness, education and support, Fertile Hope operates the only fertility preservation financial assistance program for cancer patients, including a program for men to help reduce the cost of sperm banking. For more information, to apply for financial assistance or to make a donation, please visit www.fertilehope.org or call (888) 994-HOPE.

About the Lance Armstrong Foundation
At the Lance Armstrong Foundation, we fight for the 28 million people around the world living with cancer today. There can be – and should be – life after cancer for more people. That’s why we kick in at the moment of diagnosis, giving people the resources and support they need to fight cancer head-on. We find innovative ways to raise awareness, fund research and end the stigma about cancer that many survivors face. We connect people and communities to drive social change, and we call for state, national and world leaders to help fight this disease. Anyone anywhere can join our fight against cancer. Join us at www.livestrong.org.

About H. Lee Moffitt Cancer Center & Research Institute
Located in Tampa, Florida, Moffitt Cancer Center is an NCI Comprehensive Cancer Center — a designation that recognizes Moffitt’s excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt currently has 15 affiliates in Florida, one in Georgia and two in Puerto Rico. Additionally, Moffitt is a member of the National Comprehensive Cancer Network, a prestigious alliance of the country’s leading cancer centers, and is listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer. Moffitt’s sole mission is to contribute to the prevention and cure of cancer.
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For the full story, and more on the Moffitt Cancer Center, visit this site.

I recently ran across an article by Fiona Macrae written on October 29, 2009 from Mail Online entitled “No men OR women needed: Scientists create sperm and eggs from stem cells”. I proceeded to read this article before I read the actual scientific manuscript that it was based on; the article itself makes several very big claims: 1) the research could change the face of parenthood, 2) the research could be the cure for infertility and 3) it may soon be possible for children to be born through entirely artificial means. For the last few years, there have been several outrageous media outlets that make a practice of taking an interesting scientific manuscript and sensationalizing it as a cure for infertility, etc.

Egg and Sperm Image: Alison Kim

I continued on and read the original scientific paper they were describing in the column, “Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation;” an article published in this month’s issue of Nature. It truly is a super paper describing the role the DAZL, DAZ, and BOULE genes play in the progression of embryonic stem cells to primordial germ cells (PGCs) and the subsequent development into a haploid gamete. Interestingly, this group isolated fluorescently-tagged PGCs that were developed from embryonic stem cells in culture (previously shown), but for the first time demonstrated that DAZL, DAZ, and BOULE are upregulated in order to induce these PGCs to begin meiosis and then arrest at early prophase of meiosis I.

What the scientific paper did not describe, or even hint at, was that this science would be a cure for infertility.  What this paper does, however, is attempt to clarify another step in the process of early germ cell formation that may be used as a tool for elucidating critical steps in male and female infertility. There is not one simple solution to infertility. I urge all scientists and non-scientists to be objective about outrageous claims that are made about cures and answers and to read the actual scientific papers and find the true messages behind the science.

Image: Celsias.com

The Fall 2009 Oncofertility Consortium’s Virtual Grand Rounds hosted Dr. David Wildt of the Center for Species Survival at the Smithsonian National Zoo for his talk entitled “Sex, Wildlife and Intensive Management”.  Joining him in giving this seminar were Dr. Nucharin Songsasen and Dr. Pierre Comizzoli, also of the National Zoo.  Dr. Wildt began by addressing the role of the reproductive sciences in wildlife management and the challenges faced in this field.  One of the main challenges is the lack of knowledge that is compounded by the incredible diversity that exists. For example, of 5500 mammalian species, only about 100 have been studied with respect to reproductive biology.  This is partially reflected in the reproductive biology literature: approximately 10% of publications in the field relate to wildlife, compared to 36% relating to the “role model” species, rodents and cattle.  Of the species that have been studied, there are great differences in reproduction.  To illustrate this, Dr. Wildt described both the Great Pandas which spend less than 1% of their lives in estrus, the time it is possible for them to become pregnant, and bats which have the capability of storing sperm, not just for days or weeks, but for months! This diversity can also be found within species such as canids: the domestic dog has spontaneous estrus with no seasonality however, the Maned Wolf only ovulates in the first half of the year and only in the presence of males.  Dr. Wildt talked at length of how the information gathered is put to practical use in species management, as well.  In 1996, Dr. Wildt was part of a multidisciplinary team that went to China to work on reversing the stagnation of the panda population.  By applying the knowledge gained from this research team, the number of pandas (in captivity) has been increased from 104 in 1998 to 292 in 2009.  Soon this population will be self sustaining and reintroduction of pandas to the wild will commence.  Dr. Wildt stressed that reproductive science is more than just ARTs and that often species management can be done purely by understanding the factors that affect an animal’s fertility, such as environmental influences. For example, switching from small cages to a more natural enclosure lowered the stress of a colony of Clouded Leopards in Thailand, enabling natural reproduction to occur.

Dr. Wildt then turned it over to his colleagues Dr. Songsasen and Dr. Comizzoli to describe what is on the horizon for reproductive sciences in wildlife and species management.  Dr. Songsasen and Dr. Comizzoli updated us to the latest advances at the bench using the domestic dog and cat as models for wild canids and felids, respectively.  These species are important because they can serve as a model for many human diseases such as diabetes, retinitis pigmentosa and cancer.  There are also parallels with humans and fertility.  For example, teratospermia is seen in cats with very high frequency (~60%).  Dr. Songsasen described her work with the domestic dog and the successes with in vitro follicle culture.  Using the alginate culture system developed by the Woodruff lab, preantral follicles can be cultured and demonstrate hormone production.  Dr. Songsasen discussed the impacts of including various additives to the culture system including FSH and LH and also how the age of the animal affects the culturing.  Dr. Comizzoli then went on to describe his work with in vitro maturation of domestic cat oocytes and with vitrification of ovarian tissue.  Upon thawing of cortical strips, they are able to demonstrate that about 80% of the original structure is preserved and about 70% of the primordial follicles are viable.

Thanks to Drs. Wildt, Songsasen, and Comizzoli for excellent examples of how non-typical animal models can be used for oncofertility research, and the ways we can pay these animals back by using our findings to help sustain their populations!

The presentation will be posted for viewing here within the next few days!

A few weeks ago world leaders came together for a meeting at the United Nations building in New York to discuss a whole host of issues facing the global community ranging from the proliferation of nuclear weapons to climate change.  While, weeks later, the conference still may be most famous for its discussion of mushroom clouds the meeting also yielded a less covered but equally important fallout for the way policy makers address women’s issues.

The UN, at the conference, consolidated four separate agencies focussed on women’s issues into one much more powerful group, UNIFEM.  In addition to improving organizational efficiency, the new über-agency hopes to more quickly and effectively address global issues that disproportionately affect women.  Chief among these issues are health concerns.  UNIFEM cites, among other statistics that women in sub-Saharan Africa aged 15-24 are 6 times more likely than their male counterparts to test positive for HIV.

UNIFEM, though, is extending its sights far beyond HIV and even beyond addressing sexual assaults, poverty, and political representation, all of which are most certainly on the to-do list.  The agency seeks to expose and attack gender inequality issues wherever they exist, whether it be on the battlefield, in the halls of congress, or within the walls of a hospital.

This is, in many ways, an ambition shared by Oncofertility Consortium and The Institute for Women’s Health Research.  These two organizations have put their full efforts behind expanding clinical trials on women’s health issues and improving women’s fertility preservation options, already to tremendous success.  Whether it’s a new international agency, a nationwide collaboration between basic science researchers and clinicians, or as an ever-growing database in the state of Illinois, the potential of this increased attention to women’s issues on all levels and in all arenas is should be exciting to women (and men) everywhere.

(via CNN)

Congratulations to Ariella Shikanov on receiving the IBNAM-Baxter Early Career Award.  She will investigate a combination of natural and synthetic hydrogels and drug delivery technology to maximize ovarian tissue transplantation.

The full story can be found here!

Next week, October 17, several of our Oncofertility Consortium members will be participating on a panel at the American Society for Bioethics and Humanities conference in Washington, DC. Their panel title is:  “From Lab To Bedside To Patient And Back Again: Gendered Responses To Questions About Fertility And Cancer Treatment And Their Clinical And Research Implications.” Below is an abstract for the meeting, as well as a quick summary of what each presenter will be talking about. If you happen to be attending the meeting, the panel will be held at 5:45-6:45; it promises to be interesting!!

Abstract
Because of recent breakthroughs and improved treatments, more people who are diagnosed with cancer survive. And many of these people are young, either in their childbearing years or survivors of childhood cancer. Indeed, one estimate is that by 2010 one of every 250 adults will be a survivor of childhood cancer. But while more aggressive treatments have allowed more young people to survive cancer, these treatments have also resulted in impaired fertility for some. Oncofertility has emerged as a way to address this threat to fertility for those with cancer, and through biomedical research the field is actively developing new ways to help those afflicted with cancer preserve their ability to have biological children.

Oncologists focus on treating a patient’s cancer, but cancer is more than a physical illness for the patient. Cancer, and its implications, has social, cultural, and familial repercussions for patients as well. One such implication is cancer-related infertility. As a result of improved survivorship rates, cancer-related infertility will become a greater concern for patients and their families as the growing cohort of childhood cancer survivors begins to age. Oncofertility is necessarily interdisciplinary, bridging biomedical and social sciences such as bioethics, law, and religion, in a broader effort to examine issues regarding a person’s fertility concerns, choices, and options. In this panel, we will raise the following questions: How are patients affected by infertility as a result of cancer treatment in their day-to-day lives? How is a cancer patient’s sense of self changed because of the possibility (or reality) of infertility? Are these responses different for men and women? And how do their responses affect treatment options – how do (or should) patients’ responses, desires, and beliefs affect treatment options that are part of standard therapy and/or are part of new research?

Panel members:
1) Jacqueline Jeruss, MD, PhD, Assistant Professor, Department of Surgery, Northwestern University: Dr. Jeruss, a member of the Oncofertility Consortium, will provide an overview of clinical aspects of oncofertility, describing her experience with patients at the bedside. Furthermore, she will explain the goals of the clinical side of the Oncofertility Consortium, how they respond to patient needs and demands, and what clinicians have achieved thus far.
2) Shauna Gardino, MPH, Clinical Research Coordinator, Oncofertility Consortium, Northwestern University: Ms. Gardino will discuss the Oncofertility “Quality of Life” survey she is conducting, specifically, the questions that are asked, why they are asked, and what the results are so far.
3) Sarah Rodriguez, PhD, Research Fellow, Oncofertility Consortium, Northwestern University: Dr. Rodriguez will analyze how the social implications of infertility in our culture, which places a high value on women bearing children, affects women with cancer and their fertility decisions.
4) Lisa Campo-Engelstein, PhD, Research Fellow, Oncofertility Consortium, Northwestern University: Dr. Campo-Engelstein will focus on how men’s experience with cancer and infertility differs from women’s. She will explore how social expectations of masculinity, especially sexual prowess, shape the fertility choices of male cancer patients.

Oncofertility Summer Research Experience 2009

With support from the federal stimulus package Northwestern received from the National Cancer Institute, two teachers and two undergraduates gained hands-on experience in a working lab devoted to providing new fertility options for cancer patients!

The money allowed Northwestern to bring relevant lab activities to teachers around the country and bring girls through the pipeline toward careers in science.

This video gives you an idea of what the experience was like. Check out the job summary to see if you or someone you know would be interested in doing it next summer:

http://www.osep.northwestern.edu/osep/summerfellowship/
http://www.research.northwestern.edu/

The following articles in HemOnc Today and the UAB Reporter are good examples of the public awareness beginning to take shape around fertility preservation.  Take a moment to read the articles, and let us know what you think!

UAB Reporter Online: Fertility Hopes Don’t Have to End for Cancer Patients

HemOnc Today: Discussing oncofertility-The Oncologist’s Responsibility